Tuesday, 1 May 2018

Two Abstracts for World Asthma Day

"Boys are consistently reported to have more prevalent wheeze and asthma than girls. In adolescence, the pattern changes and onset of wheeze is more prevalent in females than males. Asthma, after childhood, is more severe in females than in males, and is underdiagnosed and undertreated in female adolescents."
Almqvist et al., 2007

Abstract 1:
"Gender differences in asthma incidence, prevalence and severity have been reported worldwide. After puberty, asthma becomes more prevalent and severe in women, and is highest in women with early menarche or with multiple gestations, suggesting a role for sex hormones in asthma genesis. However, the impact of sex hormones on the pathophysiology of asthma is confounded by and difficult to differentiate from age, obesity, atopy, and other gender associated environmental exposures. There are also gender discrepancies in the perception of asthma symptoms. Understanding gender differences in asthma is important to provide effective education and personalized management plans for asthmatics across the lifecourse."
Zein & Erzurum, 2015

Abstract 2:
"Asthma is a common chronic disease that affects over 300 million people worldwide, resulting in a considerable socio-economic burden. Literature data suggest that asthma has a higher incidence in females, particularly at certain stages of pubertal development. Moreover, women seem to experience more asthma symptoms than men and to use more rescue medications, resulting in a reduced quality of life. Although several mechanisms have been proposed to explain these differences, there are not yet final data available in the literature on the role of gender in the pathogenesis of asthma and different behavior in females. Some study suggested a more prevalent hyper-responsiveness in women than in men. Nevertheless, in the literature definitive data on a possible different response to drugs used for asthma between males and females are not described. Understanding the mechanisms that underlie these gender differences in clinical history of asthma patients could give inspiration to new areas of research to obtain a more specific diagnostic and therapeutic approach gender-oriented."
Pignataro et al., 2017

- - - - - - - -
- Almqvist, C., Worm, M., Leynaert, B. (2007). Impact of gender on asthma in childhood and adolescence: a GA2Len review. Allergy, 63, 47-57.
- Pignataro, F. S., Bonini, M., Forgione, A., Melandri, S., & Usmani, O. S. (2017). Asthma and gender: The female lung. Pharmacological Research, 119, 384-390.
- Zein, J. G. & Erzurum, S. C. (2015). Asthma is Different in Women. Current Allergy and Asthma Reports, 15(6), LINK
- photograph "Smog alert, Los Angeles, 1979" via; more photographs: LINK


  1. Replies
    1. It's a wonderful one + it's from the 1970s = double wonderful. Many thanks for passing by, Wim!